{"id":8698,"date":"2020-11-30T13:20:00","date_gmt":"2020-11-30T18:20:00","guid":{"rendered":"https:\/\/vetanco.com\/en\/?p=8698"},"modified":"2026-03-10T09:35:51","modified_gmt":"2026-03-10T13:35:51","slug":"incuinta-bioinnovo-apply-knowledge-fight-covid19","status":"publish","type":"post","link":"https:\/\/vetanco.com\/en\/incuinta-bioinnovo-apply-knowledge-fight-covid19\/","title":{"rendered":"INCUINTA and Bioinnovo apply their knowledge to fight COVID19"},"content":{"rendered":"\n\n\n<p><strong><em>Argentine researchers used two different platforms to neutralize the virus with \u201cnanobodies\u201d derived from llamas and egg immunoglobulins. How do they work?<\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"693\" src=\"https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-1-1024x693-2.jpg\" alt=\"\" class=\"wp-image-8699\" srcset=\"https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-1-1024x693-2.jpg 1024w, https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-1-1024x693-2-300x203.jpg 300w, https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-1-1024x693-2-768x520.jpg 768w, https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-1-1024x693-2-510x345.jpg 510w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>AS A TEAM. WORKING TOGETHER, THE BIOINNOVO WORK GROUP CONTINUES TO GROW.<\/p>\n\n\n\n<p>Have no doubts that it is the science that will save the world from the COVID19 pandemic. Argentine researchers have had a prominent position at a global level in this field by developing preventive and therapeutic technologies, which now include two virus-neutralization methods: nanoantibodies derived from llamas (\u201cnanobodies\u201d) and immunoglobulins (IgY) generated in chicken egg yolk.<\/p>\n\n\n\n<p>\u201cWe know how to produce antibodies, and this is not negligible when it comes to progress towards health sovereignty. It allows Argentina to have the same tools developed in other countries,\u201d asserted Andr\u00e9s Wigdorovitz and Viviana Parre\u00f1o in an interview for&nbsp;<a href=\"https:\/\/www.motivar.com.ar\/\"><strong>MOTIVAR<\/strong><\/a>&nbsp;on those advances.<\/p>\n\n\n\n<p>It should be clear that these are two different platforms. One platform generates recombinant monoclonal antibodies (nanobodies) derived from llamas, developed by INCUINTA and CONICET. The other was developed by&nbsp;<a href=\"https:\/\/www.bioinnovo.com.ar\/intro\/\">Bioinnovo<\/a>, a public-private partnership between&nbsp;<a href=\"https:\/\/www.argentina.gob.ar\/inta\">INTA<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/vetanco.com\/\">Vetanco<\/a>, to generate antibodies produced in chicken egg yolks (IgY), which have already been applied for the prophylactic or therapeutic treatment in cattle.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Innovation: recombinant monoclonal nanoantibodies<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"216\" height=\"190\" src=\"https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-Parreo-216x190-2.jpg\" alt=\"\" class=\"wp-image-8700\"\/><\/figure>\n\n\n\n<p>VIVIANA PARRE\u00d1O. INCUINTA.<\/p>\n\n\n\n<p>\u201cThis technology started to be applied in the 1990s. It is based on camelids, which have a different type of immunoglobulin G in their serum,\u201d explained Dr. Viviana Parre\u00f1o, a leading researcher at INCUINTA. \u201cThe process starts by immunizing llamas with the spike protein of coronavirus, which is the protein that induces the production of neutralizing antibodies. Blood is collected from llamas, a library with antibody sequences against that antigen is generated, from which neutralizing antibodies are selected.\u201d This work was carried out in a partnership with the CONICET team led by Itat\u00ed Ib\u00e1\u00f1ez. INCUINTA has also developed \u201cnanobodies\u201d against Rotavirus, Influenza, Norovirus, Rabies, Bovine Viral Diarrhea and Rio Cuarto corn viral disease, among others.<\/p>\n\n\n\n<p>Nanoantibody research is also progressing in China, the USA, Switzerland, Belgium, and Sweden, where, as in Argentina, these molecules are being investigated to be included in saline solution and administered to people via nebulization to reach the entire respiratory tract up to the bronchi. \u201cThrough this non-invasive route, the molecules reach the site of virus replication to neutralize it, thereby limiting the viral infection,\u201d explained Parre\u00f1o. \u201cWe want to test it as a preventive measure to reduce the infection risk, and also in patients who have already been infected.\u201d The researcher told&nbsp;<strong>MOTIVAR<\/strong>&nbsp;that INCUITA contacted the University of Virginia, USA, to start testing the product using a mouse model.<\/p>\n\n\n\n<p>\u201cThe product will then be scaled up, applying good manufacturing practices, before being tested in humans, and for this, we need a private partner that has all the required infrastructure,\u201d added Parre\u00f1o.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>IgY immunoglobulins<\/strong><\/h4>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"199\" height=\"190\" src=\"https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-2-300x286-199x190-199x190-1.jpg\" alt=\"\" class=\"wp-image-8701\"\/><\/figure>\n\n\n\n<p>ANDR\u00c9S WIGDOROVITZ. BIOINNOVO.<\/p>\n\n\n\n<p>Highlighting the importance of the public-private partnership between INTA and Vetanco, Andr\u00e9s Wigdorovitz described Bioinnovo\u2019s development of IgY against the calf diarrhea complex.<\/p>\n\n\n\n<p>IgY immunoglobulins are antibodies produced in response to the inoculation of chickens with selected antigens, such as bacteria, viruses, parasites, or proteins. \u201cOur biological product (Bioinnovo DNT) has been used for the prevention of rotavirus, coronavirus,&nbsp;<em>Salmonella,&nbsp;<\/em>and&nbsp;<em>E. coli&nbsp;<\/em>infections in calves. Based on our experience and on the work of Marina Bok, a member of our team that did her doctoral thesis on coronavirus, we produced polyclonal antibodies against SARS CoV2,\u201d explained Wigdorovitz. \u201cWe got together with the COVID19 Consortium of the School of Exact Sciences (UBA), which provided us the RBD protein to formulate the vaccine and start to immunize chickens. Thanks to Bioinnovo\u2019s know-how, we already knew how and when to vaccinate the chickens, the vaccine dose, and had mastered the harvesting and extraction techniques. After all, we manufacture up to 15 tons of IgY DNT annually.\u201d<\/p>\n\n\n\n<p>Wigdorovitz mentioned that the Malbr\u00e1n Institute and the University of Virginia highlighted the neutralizing potency of the IgY obtained. The product will probably be made available in gel capsules to protect the digestive tract by oral administration. Australia is also testing this technology in people but by nasal route.<\/p>\n\n\n\n<p>\u201cThe objective is not to use it in critical patients, but to reach symptomatic people quickly to reduce the infectious burden,\u201d said Wigdorovitz.<\/p>\n\n\n\n<p><strong>Argentine science<\/strong><\/p>\n\n\n\n<p>In the interview of&nbsp;<a href=\"https:\/\/www.motivar.com.ar\/\"><strong>MOTIVAR<\/strong><\/a>, both Wigdorovitz and Parre\u00f1o said that they share a passion for science and that they believe that Argentine researchers have a pivotal role to play when thinking about the future. \u201cWe are committed to developing innovations to solve real problems. We are the fruit of public education, and we endeavor to demonstrate that realities can be transformed,\u201d said Andr\u00e9s Wigdorovitz. Viviana Parre\u00f1o concluded: \u201cWe are at the same level as the great nations, striving to contribute to achieving national health sovereignty, for which it is strategic to obtain the commitment and investment of the private sector.\u201d<\/p>\n\n\n\n<p>PUBLIC-PRIVATE PARTNERSHIP<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u201cEverything depends on the development of knowledge networks\u201d<\/strong><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"285\" height=\"190\" src=\"https:\/\/vetanco.com\/en\/wp-content\/uploads\/2024\/09\/Bioinnovo-Winokur-300x200-285x190-1.jpg\" alt=\"\" class=\"wp-image-8702\"\/><\/figure>\n\n\n\n<p>Vetanco and a team of INTA researchers have worked together for more than 15 years. Bioinnovo, the public-private company that links us, is the tool that managed to take promising technologies from the laboratory to the farmer. Vedevax, the vaccine targeted at the immune system to control the BVD virus, and Bioinnovo IgY DNT are some of the product lines we are currently working on.<\/p>\n\n\n\n<p>The efficacy of the Bioinnovo product in neutralizing Coronavirus and bovine Rotavirus has been demonstrated both in the field and in tests carried out by Senasa (Argentine national food safety and quality agency). The next step of our permanent screening of other possible uses of our viral animal disease platform was a project to check its potential application for the control of COVID19 by generating IgY against the RB protein. This innovation may advance to a new development phase after testing by the Malbr\u00e1n Institute, CONICET, and Virginia Tech University. We hope it may be a further option for the management of some COVID19 cases.<\/p>\n\n\n\n<p>How did we reach this and other milestones? For Vetanco, everything depends on the development of knowledge networks. To continuously build research laboratories, the company\u2019s growth has physical, economic limits, and efficiency limitations. Therefore, we try to partially or fully include other excellence groups in our network.<\/p>\n\n\n\n<p>For example, during the last World Vaccine Congress, we presented Biotech Vac at a conference in which Dr. Antony Fauci participated. This product was conceived by a researcher trained at the University of Arkansas and further developed by Vetanco with the support of Fontar-Mincyt nine years ago. It was then tested in Brazil, INTA, and Georgia Southern Poultry. Manufacturing agreements have been made with a company in the US, where its license has been requested for the Northern Hemisphere. It is produced by Vetanco in the CDV Laboratory in Argentina for the Southern Hemisphere market.<\/p>\n\n\n\n<p>Bioinnovo case underlines the invaluable work of many INTA researchers, who, in collaboration with Vetanco, continue to search for new applications and uses for these platforms. All this was possible by working together within a shared knowledge and economic framework.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.linkedin.com\/in\/luciano-aba-b806a0a\/\">Luciano Aba<\/a>&nbsp;\u2013&nbsp;<a href=\"https:\/\/www.motivar.com.ar\/\">Motivar Newsletter<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Argentine researchers used two different platforms to neutralize the virus with \u201cnanobodies\u201d derived from llamas and egg immunoglobulins. How do they work? AS A TEAM. WORKING TOGETHER, THE BIOINNOVO WORK GROUP CONTINUES TO GROW. Have no doubts that it is the science that will save the world from the COVID19 pandemic. Argentine researchers have had [&#8230;]\n","protected":false},"author":8,"featured_media":8703,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28],"tags":[19,95,96,97,94,62,20,93,18],"class_list":["post-8698","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-bioinnovo","tag-bioinnovo-dnt","tag-bioinnovo-igy-dnt","tag-bvd-virus","tag-conicet","tag-incuinta","tag-inta","tag-motivar","tag-vetanco"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>INCUINTA and Bioinnovo apply their knowledge to fight COVID19 - Vetanco United States<\/title>\n<meta name=\"description\" content=\"Argentine researchers used two different platforms to neutralize the virus with \u201cnanobodies\u201d derived from llamas and egg immunoglobulins.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vetanco.com\/en\/incuinta-bioinnovo-apply-knowledge-fight-covid19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"INCUINTA and Bioinnovo apply their knowledge to fight COVID19 - 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